Needle-Free Delivery of Lidocaine

single-center, randomized, double-blind, placebocontrolled, single-dose, parallel-group study



Local Anesthesia

To use the needleless injector as a means of administering xylocaine or bupivicaine, or its isomers, subcutaneously
for field, ring or sensory nerve block anesthesia.

William S.Yale, M.D.

J Turk Anaesth Int Care 2010; 38(2):122-128
The Efficacy of Needle-free Injection System (INJEX) in Relieving the Pain of Spinal Needle Insertion


No-needle local anesthesia for adult male circumcision.


Dynamic control of needle-free jet injection Stachowiak JC, Li TH, Arora A, Mitragotri S, Fletcher DA. 2009 Apr 17;135(2):104-12. Epub 2009 Jan 21.




Jet Injection of 1% buffered lidocaine versus topical ELA-Max for anesthesia before peripheral intravenous catheterization in children: a randomized controlled trial.



A novel needle-free powder lidocaine delivery system for rapid local analgesia Zempsky WT, Robbins B, Richards PT, Leong MS, Schechter NL. 2008 Mar;152(3):405-11. Epub 2007 Oct 22.



Needle-Free Delivery of Lidocaine for Reducing the Pain Associated with the Fine-Needle Aspiration Biopsy of Thyroid Nodules: Time-Saving and Efficacious Procedure, Alptekin Gursoy, Derun Taner Ertugrul,…. Department of Endocrinology and Metabolism.



Infiltration anaesthesia in dentistry by using Injex, Dr. E. Körperich FU Berlin

Needle-less local anesthesia: clinical evaluation of the effectiveness of the jet anesthesia Injex in local anesthesia in dentistry; Dabarakis NN, Alexander V, Tsirlis AT, Parissis NA, Nikolaos M.; 2007 Nov-Dec;38(10):E572-6.



38(10): E572-6.

Needle-less local anesthesia: clinical evaluation of the effectiveness of the jet anesthesia Injex in local anesthesia in dentistry.




Needle-free injection-science fiction or comeback of an almost forgotten drug delivery system?



104(11):4255-60. Epub 2007 Mar 6.

Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets.



Comparison of the systems used for providing local anesthesia in dentistry–the Wand (Milestone Scientific) and Injex (Rosch) Zarzecka J, Go≈?czowski K, Kesek B, Darczuk D, Zapa≈?a J. 2006;63(12):1304-9.



Needle-free liquid jet injections: mechanisms and applications.



A comparison of a needle-free injection system for local anesthesia versus EMLA for intravenous catheter insertion in the pediatric patient. Jimenez N, Bradford H, Seidel KD, Sousa M, Lynn AM. 2006 Feb;102(2):411-4.



150(3):455-61.Assessment of the biological performance of the needle-free injector INJEX using the isolated porcine forelimb.



Vitro-Tec Entwicklungs-GmbH, Wiesenweg 10, D-12247 Berlin, Germany.




Clinical evaluation of the INJEX system, a local anesthesia system without needles: a comfort evaluation study.



Needle-free’ delivery of local anesthesia: a valuable option in pediatrics, Splinter WM, 2002;4(6):349-52.



Anesthetic Effective Potential of a Needle-free Injection System, G. Saleh, A. Michaelis, H. Lang, W. Raab, Poliklinik für Zahnerhaltung Düsseldorf, Quintessenz, 53, 9, 913-920 (2002)



Clinical evaluation of the effeciency of anesthesia nd patient preference using the needle-less jet syringe in pedriatriac dental practice, Munshi et al., J Clin Pediatr Dent (2001) 25-2: 131-6


Clinical evaluation of the efficacy of anesthesia and patient preference using the needle-less jet syringe in pediatric dental practice. Munshi AK, Hegde A, Bashir N. 2001 Winter;25(2):131-6.

Adjuncts to local anesthesia: separating fact from fiction, wong et al., J.Can Dent Assoc (2001) 67:391-7



Evaluation of a needle-free injection system for local anaesthesia prior to venous cannulation.



A new route, jet injection of lidocaine for skin wheal for painless intravenous cathererisation, Zsiigmond et al., Int J Pharmacol Ther (1999) 37-2: 90-9






A new route, jet injection for anesthetic induction in children. IV: Midazolam plasma levels. Domino EF, Zsigmoid EK, Kovacs V, Olajos B, Fekete GInt J Clin Pharmacol Ther 1998 Aug; 36(8):458-62



A new route, jet injection for anesthetic induction in children-III: Ketamine pharmacokinetic studies, Domino et al., Int J Clin Pharmacol Ther (1997) 35-11: 527-30



Local anesthesia for fine-needle aspiration biospsy of palpable breast masses: the effectiveness of a jet ijection system, Florentine et al., Diagn Cytopathel (1997) 17-6: 472-6



Effectiveness of a jet injection system in administering morphie and heparin to healthy adults, Baer et al., Am J Crit Care (1996) 5-1: 42-8



Local anesthesia by yet-injection device in minor dermatologic surgery, Queralt et al., Dermatol Surg (1995) 21-7: 649-51



The efficacy and acceptability of using a jet injector in performing digital blocks, Ellis GL, Owens A; Am J Emerg Med 1993 Nov; 11(6):648-50



The needleless syringe: efficiency of anesthesia and patient preference in child dental patients, Saravia et al., J.Clin Pediatr Dent (1991) 15-2: 109-12



Studies on tissue penetration characteristics produced by jet injection. Bennett CR, Mundell RD, Monheim LM., J Am Dent Assoc. 1971 Sep;83(3):625-9.